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After 6 h of treatment with CuCl 2 , no significant dose-dependent changes or differences between cell types were detected (Fig

doi: 10.1038/s41467-021-25181-7 62

While previous research suggested that iron was the sole metal ion triggering ferroptosis, 232 emerging evidence indicates that copper can also facilitate this form of cell death under certain conditions

17 Through active or passive targeting mechanisms, nanomaterials can increase the local concentration of drugs in lung tissue lesions, control drug release, prolong drug exposure time, and improve drug efficacy while reducing side effects

Despite the clear biological sex differences that can affect drug behavior, most pharmacotherapy guidelines do not consider these differences in drug dosing regimens (Beery and Zucker 2011