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It selectively triggers GH release from somatotroph cells while avoiding significant stimulation of other anterior pituitary hormones such as prolactin, ACTH, and cortisol, distinguishing it from earlier GHRPs and making it the most selective GHRP-class compound characterised to date

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Notably, OG treatment shifted macrophage polarization toward an anti-inflammatory M2 phenotype and increased mitochondrial activity, facilitating adipose tissue remodeling and enhancing energy expenditure and thermogenesis