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In cell cultures and mouse models of HD as well as in patient samples, the levels of CSE are drastically diminished, due to the sequestration of SP1 by mHtt (Paul et al ., 2014)

These symptoms sometimes indicate incorrect injection technique, an allergic reaction to the medication, or a localized infection that requires clinical evaluation

They are part of a rapidly expanding class of incretin-based medications that includes several other notable compounds

a detectable signal such as an optical signal (e.g., fluorescence) Detection may be performed using an illumination source that provides fluorescence excitation to each of the capillaries in the anay, and a photodetector that detects resulting emission from the fluorescence excitation

FIGURE 1 Sodium-dependent vitamin C transporter 2 (SVCT2)-knockout mice die shortly after birth, with undetectable brain levels of vitamin C and diffuse hemorrhages in the cerebral cortex (Sotiriou et al., 2002