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Mice were treated with ICV PBS (control, vehicle N = 5, insulin N = 8) or 100 ng/hr leptin (vehicle N = 7, insulin N = 6) for 9-days

To further investigate whether the elevated GABA/glutamate ratio benefits viral replication, JEV-infected Neuro2a cells were treated with exogenous addition of GABA

This experiment was designed to study the role of 5-HT in acetaminophen-induced hepatotoxicity

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Proteomic analyses identified DNA Damage Inducible Transcript 4 (DDIT4) as one of the key pro-death effectors in this process