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Restraint stress-induced immunosuppression is associated with concurrent macrophage pyroptosis cell death in mice

Thromboembolic diseases of interest included ischaemic heart disease and myocardial infarction, ischaemic stroke or systemic embolism, peripheral artery disease or acute limb ischaemia, thrombosis in unusual sites such as cerebral venous sinus thrombosis, and venous thromboembolism

Iadecola C, Buckwalter MS, Anrather J

We examined the effect of Fer-1 and/or zVAD on DOX-induced cell death at each time point and found that zVAD or Fer-1 partially prevented DOX-induced cell death, while the concomitant inhibition of ferroptosis and apoptosis with Fer-1 and zVAD fully prevented DOX-induced cell death at any time point (Figure 9B and Supplemental Figure 9)

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