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A woman may have difficulty getting pregnant if she does not ovulate regularly or at all

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Furthermore, a near-complete depletion of CD20 + B cells in minor salivary glands and a greater and more sustained depletion of peripheral CD19 + B cells were observed with belimumab combined with rituximab compared to monotherapies (104)

While the median time of developing autoimmune breakthrough, adverse events vary from 3 to 12 weeks depending on the organ system involved, these toxicities may present themselves earlier in those with underlying conditions