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In this context, disruption of temporal coordination, rather than hormone abundance alone, may limit effective engagement of melatonin-dependent immunoregulatory pathways

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Sci Rep 11(1):19768

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226 Interaction mechanism in multi-organs Abnormalities in cytokine levels in the brain and peripheral organs, disruption of the brain/immune system balance, and dysfunction of communication between the peripheral organs and the brain can cause neuroinflammation and depressive symptoms