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The new framework represents an important shift in how innovative therapies are assessed, strengthening collaboration between EU Member States through Joint Clinical Assessments while placing greater emphasis on outcomes that matter to patients and healthcare systems

Leishmania donovani iron superoxide dismutase A is targeted to the mitochondria by its N-terminal positively charged amino acids

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It was also shown that sprifermin increases cartilage thickness while simultaneously reducing cartilage loss [434]

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