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Statements Author contributions XB: Writing review and editing, Formal Analysis, Supervision, Methodology, Writing original draft, Project administration, Software, Data curation, Investigation, Conceptualization, Visualization, Resources, Funding acquisition, Validation

They share similarities in terms of signaling pathways, but the fundamental difference between the two lies in the fact that CARs possess an engineered scFv domain able to recognize tumor antigens not bound by MHC molecules and, instead, expressed directly on the membrane

Zinc also regulates the endolysosomal tethering machinery through the HOPS complex, whose VPS18 and VPS41 subunits contain zinc-binding RING domains essential for heterodimer formation and complex stability, which is critical for autophagosomelysosome and endosomelysosome fusion 104

In contrast, the presence of albumin was associated with an enrichment of particularly lipids and some specific amino acid metabolites extracellularly (cluster 3

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