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It mediates tissue-protective signaling distinct from the erythropoietic EPO pathway

Non-significant relationships were also reported in observations and model outputs

Can also be utilized in the modulation of transcriptional regulators like EGR1 and NAB2, which play a role in gene expression during stress responses (3)

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Conversely, the authors also found that copper deficiency decreases the formation of autophagy-initiating phagophores, which contain important ULK1/2 downstream targets ( Figure 1 )