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Organisms sense these regular external changes and synchronize their physical activities, such as behavior, food intake, energy metabolism, sleep, reproductive activity, and immune function, to increase their survival abilities ( SCN may act on somatostatinergic neurons and GH-releasing hormones (GHRH) to synchronize the GH rhythm with the light-dark cycle ( Circadian Clock System The CLOCK transcript forms a heterodimer with brain and muscle arnt-like protein 1 (BMAL1)

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These components, such as mtDNA, mitochondrial RNA (mtRNA), mitochondrial ROS (mtROS), and N-formyl peptides, can be released upon mitochondrial stress or damage