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Natural flavones like quercetin and apigenin act as TrkB agonists, directly binding to the receptors extracellular domain to activate the downstream CREB pathway, thereby reducing apoptosis, oxidative stress, and protein aggregation in cellular models of neurodegeneration (Chiu et al., 2023)

10.3390/cells11172726 Cells

These changes contribute to neuroinflammation, bloodbrain barrier (BBB) dysfunction, microglial activation, and neurotransmitter imbalances

Indeed, it has been demonstrated a role of IGF-I signaling for maintaining glomerular integrity, restoring podocyte abnormalities, inhibiting podocyte apoptosis, and alterations in the glomerular basement membrane and the adjacent endothelial cell layer [140,363]

Hu JN, Wang YM, Zhang H, Li HP, Wang Z, Han M