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10.1007/s002040000157 99

This stage is characterized by the local infiltration of tumor cells into surrounding healthy tissues, characterized by growth that does not require anchorage, along with their interaction with mesenchymal stromal and immune cells

In other words, MODA's principal mechanism is cytoprotection against cell death, with only indirect or partial influence on restoring the core cholestatic defect of bile flow dynamics, which implies that it may need to be paired with a dedicated choleretic agent for full clinical resolution

Receptors (requiring no antigen Antigen Substances that are recognized by the immune system and induce an immune reaction

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