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In patients with pre- existing seizure activity, an increase in seizure frequency and/or severity has been reported

doi: 10.1038/s41417-023-00696-x 107 MandulaJKChangSMohamedEJimenezRSierra-MondragonRAChangDCet al

Pre-existing conditions such as diabetes, cardiovascular disease, hormone imbalances, liver issues, kidney problems, or autoimmune conditions can influence how the body responds to certain peptides