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Int J Mol Sci 17(2):180

Taken together, these findings therefore confirmed that any differences that we identified in inflammatory gene expression in AT were related to any changes in circulating lipids thereby suggesting an early inflammatory AT phenotype may be a mechanism that underlies the development of metabolic disorders as a consequence of low B12 levels in maternal obesity

Adult D2KO mice have a 50% reduction in bone formation and a generalized increase in skeletal mineralization resulting from a local deficiency of T3 in osteoblasts (101)

This can lead to a buildup of fat in the liver

Apart from acetate, an important source of cytosolic acetyl-CoA is by cleavage of citrate that originated from mitochondria, catalyzed by ATP-citrate lyase 264,280,281