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The pKa, which describes the dissociation of the neutral form to the negatively charged form, of sulfadiazine is 6.5 17 , making the dissociation of sulfadiazine relevant in the environment, where even slight pH changes in the vicinity of the pKa will have a major impact on the balance between the neutral and ionized fractions (Fig

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The CO 2 /HCO 3 buffer system is an example of an open system, in which the total concentration of the components of the buffer change to keep the pH at a nearly constant value