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68 Similarly, deletion of Atg7 or LAMP2 leads to cardiomyopathy with mitochondrial defects, 67 thus emphasizing the vital link between autophagy and mitochondrial health

PD and several related neurodegenerative disorders can also been considered as proteinopathies, in which the core neurodegeneration of nigrostriatal dopaminergic neurons in PD is also associated with a more widespread cellular deposition of alpha-synuclein 8

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MOMP is regulated by members of the B-cell lymphoma 2 (Bcl-2) family of proteins, which include both anti-apoptotic and pro-apoptotic proteins

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