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Cardiovascular (Heart and Blood Vessel) Complications In rare but serious cases, B12 replacement can lead to heart and blood vessel problems: Shortness of breath Peripheral edema (swelling in legs and arms) Rapid weight gain Pulmonary edema (fluid in lungs) Congestive heart failure (heart cannot pump effectively) Blood clots in vessels These complications arise from increased blood volume, thicker blood, and sudden changes in how hard the heart needs to work

Oncogene 44 , 18201832 (2025)

Animals were tested for exploratory activity in the novel cage/environment, measured as the number of visits during the first hour in the IntelliCage, and in the familiar cage/environment, measured as the number of visits per day during the following 3 consecutive days

It can develop in anyone who performs repetitive arm, wrist, or hand movementsfrom athletes and weightlifters to carpenters, mechanics, and office workers

K.GredlerR.ChenD.SanthekadurP