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Indeed, it has been shown that continuous exposure to inflammation in the form of the viral mimic PolyI:C leads to impairment of HSC self-renewal capacity and premature aging 15

El-Bacha T, Midlej V, Pereira da Silva AP, Silva da Costa L, Benchimol M, Galina A, Da Poian AT

2.2 Signaling Pathways Many botanical drugs and natural products have practical anti-inflammatory and immunomodulatory effects through various signaling pathways

Role of the mitochondrial DNA replication machinery in mitochondrial DNA mutagenesis, aging and age-related diseases

IFN-gamma and TNF-alpha as a priming strategy to enhance the immunomodulatory capacity of Secretomes from menstrual blood-derived stromal cells