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Additionally, they offer no proven benefit beyond tirzepatide's substantial weight loss effects and may worsen anxiety or sleep disturbances

Transl Psychiatry 15:110

Insulin resistance, a common characteristic of obesity, can also influence dosage decisions, particularly with GLP-1 agonists, as they directly impact insulin secretion and sensitivity

Insurance coverage questions may depend on diagnosis, plan rules, and whether treatment is being considered for weight management, type 2 diabetes, or another clinical reason