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Oxidative stress is responsible for disturbed signalling pathways which in turn affects, for example, molecular mechanisms of apoptosis induction, impairment of mitochondrial function, protein modification, and other mechanisms

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This fragmentation fosters a competitive environment where differentiation hinges on technological capabilities, regulatory compliance, and strategic alliances, rather than solely on pricing

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Moreover, a recent study has demonstrated that tumor associated M2 macrophages secret HGF in a feed-forward manner, leading the resistance to sorafenib (Dong et al., 2019)