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The initial step involves conducting clinical trials to evaluate the safety and efficacy of PLB in PCOS patients and to validate its potential use in humans

One possible reason is straining during bowel movements, which is especially likely if you have diarrhea or constipation

Harding (1985) The brain RAS and Alzheimer's disease. Exp Neurol 223(2): 326-33

However, the demarcation between asymptomatic hyperuricemia and gout remains clinically ambiguous as only approximately 50% of patients with prolonged hyperuricemia develop gout within 15 years (Xiang et al., 2024