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The sample was collected from the fine sediment (top 1020 cm), stored in sterile 50 mL Corning Falcon tubes (Sigma-Aldrich, Gillingham, United Kingdom), and shipped in cooling boxes at 4 C to the Open University (UK) within 7 days of sampling

These types of formulations typically require stronger positioning around active ingredients, deeper skin penetration claims, and professional credibility

Intravenous administration bypasses this limitation but requires medical supervision, carries infection risk, and lacks robust efficacy data for skin lightening in published trials

Results Co-treatment of Met or CQ, and low-dose AraC more effectively inhibited NALM-6 cell proliferation This study demonstrated that AraC, Met, and CQ significantly inhibited NALM-6 cell proliferation in a dose-dependent manner

Leukemia 9(11):1799-804, 1995