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2025 Dec 4:1011:178432

& Schweizer, J

Synaptic activity is energetically expensive 20 requiring high rates of metabolism and involving high levels of Ca 2+ influx, risking elevated ROS generation that must be detoxified

Inhibition of xCT by Class 1 ferroptosis inducers, such as erastin, may induce ferroptotic cell death mainly by depletion of cellular GSH content, and subsequently lead to inactivation of glutathione peroxidase-4 (GPX4