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This is what may lead to cognitive conditions like dementia

PMID: 13 SpitschakMVanselowJ

Regarding methanol metabolism, in men and women given a single dose of aspartame (34, 100, 150, or 200 mg/kg bw), blood methanol concentrations were below the limit of detection (0.4 mg/dL) at the lowest dose [the Working Group noted that currently available methods would have better sensitivity] but significantly increased after each higher dose, and mean peak blood methanol concentrations and blood methanol AUCs increased proportionally to dose (Stegink et al., 1981b)

There may be a number of sources of this oxidative stress, including mitochondrial superoxide production, ischemia-reperfusion mechanisms and auto-oxidation of catecholamines

(54) found the activation of thromboxane B2 pathway in IL-17-high asthma patients