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These results imply that AHK could potentially rejuvenate the extracellular matrix and contribute to skin function

Extreme temperatures can also degrade the peptide itself

Some disorders of intracellular cobalamin metabolism (cblC, cblD-MMA/Hcy, cblF, and cblJ) do not only compromise the synthesis of methylcobalamin, but also the synthesis of adenosylcobalamin, cofactor of the enzyme methylmalonyl-CoA mutase, leading to elevated concentrations of both tHcy and methylmalonic acid (MMA)

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doi:10.1016/s0022-3476(88)80114-8