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During 2009 a total of 69 samples were analyzed of which 31.9% had the CVMNK haplotype whereas 68.1% were CVIET

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Until recently, it was not clear how mitochondrial dysfunction triggers the ISR

Likewise, acriflavine, an antibacterial drug that was clinically used before penicillin, was noticed to directly bind to the HIF-1 and HIF-2 PAS-B subdomain and prevents them from interacting with HIF-1, preventing the transcription of genes controlled by HIF and impairing the development and vascularization of the tumor [99,100,101]