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Our group, working with partially deficient IGF-1 mice, has demonstrated that the liver is capable of expressing IGF-1R (which under physiological conditions it does not [99]) as a defence mechanism (peer review)

[PubMed: 28732571] 250

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor- coactivator 1 regulated -secretase 1 degradation and mitochondrial gene expression in Alzheimers mouse models