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Fu X, Kao JL, Bergt C, Kassim SY, Huq NP, dAvignon A, Parks WC, Mecham RP, Heinecke JW (2004) Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation

These subunits are linked by an extracellular covalent disulfide bond and perform distinct functions

Gendron MC, Schrantz N, Metivier D, Kroemer G, Maciorowska Z, Sureau F et al

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Relative risk reduction from blood pressure reduction is similar across populations with varying absolute risk, so the absolute benefit is greater in patients who are at higher risk independent of their hypertension (for example, patients with diabetes or hyperlipidemia), and such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal