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The problem arises when inflammation becomes chronic, persisting long after the initial injury should have resolved

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Reasonable assurance of safety [could] only be achieved by abolishing the use dental amalgam or by placing it into Class III. [FDA provided an interim response to this petition on January 21, 2010, with no substantive value.] In response to these and other petitions, the FDA held hearings before a Scientific Advisory Panel in December 2010

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Spine (Phila Pa 1976) 32 (7), 816823