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Therefore, we aimed to identify factors affecting PK variability of busulfan in pediatric allogeneic hematopoietic cell transplantation (HCT) recipients and investigate the effect of glutathione S-transferase (GST) activity on busulfan metabolism using a semi-mechanistic population PK model

It is important to note that oral doses may be degraded by the digestive system, compromising their effectiveness

doi: 10.1371/journal.pone.0172486

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Fournir la forme mthyle procure donc un coenzyme qui ne dpend pas des tapes de conversion requises par la cyanocobalamine, ce qui est la principale raison de son choix dans les contextes de recherche axs sur la mthylation et le mtabolisme un carbone