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Preclinical evidence, based on the colorectal distension model in rats and mice and the writhing test in mice, indicated that cannabinoid receptors, located in the CNS and/or at peripheral sites, may be involved in visceral pain and the development of visceral hypersensitivity [111,113,135,136,137,138,139,140,141,142]

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511 It facilitates the ubiquitination and degradation of IRE1 in FLS from mice with collagen-induced arthritis (CIA), protecting synovial cells from ER stress-induced apoptosis