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Phase I-II reactions in intestinal tissue and liver The reaction involves two phases of polyphenolic compounds in the intestine and liver, respectively, and consists mainly of a combination of reactions including absorption as well as glucuronidation, sulfation, and methylation, to be converted into more water-soluble metabolites and rapidly metabolized so that they can be removed by urine and bile and readily excreted from the body 54

: Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFR L858R/T790M inhibitors