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Osteonecrosis of the Jaw Osteonecrosis of the jaw has been reported with zoledronic acid [see Warnings and Precautions (5.4)]

Because it is unlikely that Glu would be modified by 4-OXO-DHA, our results support that 4-OXO-DHA (an electrophilic Michael acceptor) can covalently bind to the peptide containing the sequence of the active site of NF-B p50 protein to form a covalent linkage with the nucleophilic Cysteine-S 62 residue (marked in bold and italic in Table 1)

Your research protocol should pre-determine the doses you intend to study

A general feeling of discomfort, uneasiness, or being unwell