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For example, some studies have found that the secondary mutations of D1228N/V and Y1230C in the MET kinase domain are the main mechanisms for acquired resistance to crizotinib in METex14 patients receiving c-MET inhibitor treatment [149, 150]

This misfire causes chronic inflammation and tissue damage

Generally, yes, but it is advisable to consult with a healthcare professional for personalized advice

doi:10.1021/ja01294a502