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Controversies exist over the TP53 mutation status dependencies of APR-246

This adaptation allows them to tolerate massive oxidative loads that would trigger apoptosis in non-malignant cells, effectively creating a privileged redox state that immune cells lack

These studies and others like them demonstrate the thioredoxin system plays a critical role in the maintenance of the S-nitroso proteome by two distinct mechanisms: (1) reduced Trx denitrosates low-molecular weight and protein S-nitrosothiols

The key to the diverse roles of different classes of GSTs is due to their structure, specifically the composition and spatial localization of amino acid residues composed in the enzymatic active sites

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