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PMID: 38319329

10.1039/c9ay02696g 157 MoradlouO.RabieiZ.DelavariN

However, the challenges such as non-selective cytotoxicity, low water solubility, poor bioavailability, low bioactivity, weak affinity and scarcity of sources in natural products limit their development to new pharmaceuticals

PLoS One 4 , e5004, (2009)

All these effects could lead to a potential increase in quality-adjusted life years for patients receiving HFR compared to other dialysis techniques, which would be sufficient to justify the additional cost, as has been described with other adsorptive techniques.95 Guidance for future research Despite the potential advantages of HFR over high-flux HD and OL-HDF with high convective transport, this technique could benefit from improvements in the design of currently available prototypes