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Gut microbiota derived indole-3-acetic acid ameliorates precancerous inflammatory intestinal milieu to inhibit tumorigenesis through IL-35

High concentrations of C5, an essential protein for MAC genesis, as well as MAC are associated with RGC apoptosis and axonal degeneration in the optic nerve head and pharmacological inhibition of the complement cascade reduces both apoptosis and MAC levels (Soto and Howell, 2014)

Most existing investigations tend to focus on either small peptides or larger bioactive peptides independently, resulting in limited data on their relative efficacy, mechanistic differences, and potential synergistic applications within the same experimental frameworks