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Anti-inflammatory and antioxidant actions also contribute to its synergistic anticancer effects by dampening STAT3-driven tumor-promoting feedback and inhibiting oncogenic pathways including mTOR, PI3K/Akt, and Wnt/-catenin (Li et al., 2018

Role of glucose metabolism in aggressive phenotype of fibroblast-like synoviocytes: latest evidence and therapeutic approaches in rheumatoid arthritis

Strategies aimed at reducing high glucose levels by employing sodium-glucose cotransporter-2 inhibitors (SGLT2i) have been shown to significantly lessen the onset of cellular senescence, potentially attributed to the synthesis of -hydroxybutyrate (Kulkarni et al., 2022)

doi: 10.1155/2010/484987

Our observed complex structure differs fundamentally from all previously published models of the hTrxR1hTrx1 complex and provides new insights into the catalytic mechanism of large, eukaryotic TrxRs