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This inhibitor shows a high selective inhibitory ability of Mtb fumarase, but has no effect on the human homolog [292]

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The resulting oxidative stress promotes DNA breaks and upregulates PARP-1 expression (27)

Circulation 103 : 10061011 Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SW, Smith RS, Bottiglieri T, Bagley P, Selhub J, Rudnicki MA, James SJ and Rozen R (2001) Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition

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