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Environmental factors associated with IBD pathogenesis include stress, smoking, unhealthy lifestyle, and poor hygiene, whereas the use of non-steroid anti-inflammatory drugs, antibiotics, or appendectomy has also been associated with IBDs [36]

It is believed that the toxic effects of Hg on the CNS and cardiovascular system are related to the increase in ROS production

~2.95, P = 0.0158)

Preclinical models of OM have demonstrated that modulating these regulators (e.g., PTGS2 inhibition leading to GPX4/SLC7A11 upregulation) can alleviate disease pathology (Zhou SR