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In five multiple-dose studies in healthy subjects (N=82) and in subjects with epilepsy (N=86), when administered under fasting and nonfasting conditions, divalproex sodium extended-release tablets given once daily produced an average bioavailability of 89% relative to an equal total daily dose of divalproex sodium delayed-release tablets given BID, TID, or QID

Cline, H

Patients present with mild to severe chronic hemolytic anemia and eventually develop hemochromatosis and its complications, which may be exacerbated by transfusion and coinheritance of other hematopoietic disorders

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doi: 10.1016/j.bbamcr.2018.02.010 40 XuTGaoPHuangYWuMYiJZhouZet al