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PLoS Computational Biology

Heat Shock Proteins HSPA1 and HSP90AA1 Are Upregulated in Colorectal Polyps and Can Be Targeted in Cancer Cells by Anti-Inflammatory Oxicams with Arylpiperazine Pharmacophore and Benzoyl Moiety Substitutions at Thiazine Ring

Consequently, the inhibition of Gln leads to a deficiency of intracellular nutrients, which can impede tumor progression

These results provide evidence that HsaGSTA3-3, and also HsaGST A1-1, catalyze steroid isomerization in coordination with HSD3B2 to produce progesterone and 4-androstenedione from their delta5-precursors pregnenolone and dehydroepiandrosterone in steroidogenic cells