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In early preclinical stages of AS, IL-23 might kick-start inflammation, but once disease is established, memory T cells and resident entheseal cells could sustain IL-17 production without IL-23[27]

Phosphorylation regulates signal transduction and the intracellular localization of proteins

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Initially, the fluorescence of reaction product increased proportionally with increase of concentration of MBB in accordance with Beer-Lambert law

It is very important that administration is monitored by a specialist to avoid overdosing and to maximize the therapys benefits.