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After activation, they influence metabolic gene expression and interact with coactivator networks that include PGC-1 and PGC-1

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Good dietary sources include meat, poultry, fish, eggs, and dairy foods. Vegetarians, vegans, and people with limited intake of animal products often rely on fortified foods such as plantbased milks, breakfast cereals, or nutritional yeast, but these may not fully meet daily needs in every case

In these cases, an autoimmune reaction destroys intrinsic factor (another step in its absorption), preventing B12 absorption

The time it takes for vitamin B12 (cobalamin) treatment to produce noticeable effects varies considerably depending on the severity of deficiency, the route of administration, and individual patient factors