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50,51 While necroptosis enhances antigen availability, leukocyte infiltration, and DC cross-presentation, the robust induction of cytokines such as IL-12 and IL-15 generally depends on additional PRR engagement or proinflammatory cues that fully activate DCs via nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) and interferon regulatory factor (IRF) signaling pathways

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the later dosing and titration sections explain why response and tolerability matter more than advancing on a fixed calendar