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Exploratory endpoints included achieving 15% and 20% weight loss, and patient-reported outcomes assessed using the SF-36 v2.0 and the Three-Factor Eating Questionnaire (TFEQ-R18 v2)

Muscle Mass and Body Composition Research in growth hormone-deficient and intact animal models showed effects on lean body mass: 15.3% increase in body weight in GH-deficient mice treated with ipamorelin over 9 weeks Enhanced protein synthesis and nitrogen retention in skeletal muscle tissue Dose-dependent effects on body weight gain and lean mass accretion Preserved muscle mass during catabolic conditions in experimental models Studies using DEXA scanning confirmed increases in lean tissue mass with corresponding reductions in fat mass percentage

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Compare week 12 with the week-0 baseline and week 6