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TGF- receptor activation and phosphorylation trigger a regulatory circuit of activating and inhibitory SMAD proteins and increased activation of the TGF- signaling pathway either by a loss of negative feedback or constitutive activation has been associated with the myelosuppression and ineffective erythropoiesis in myelodysplastic syndromes (MDS)

Noonan syndrome A dysmorphic syndrome associated with phenotypical congenital heart defects and short stature (OMIM 615355)

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in Brain Peptides: A New Endocrinology, 7188 (Elsevier/North-Holland Biomedical Press, 1979)