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[DOI] [PubMed] [Google Scholar] 47.Katz MD, Kligman I, Cai L-Q, Zhu Y-S, Fratianni CM, Zervoudakis I, Rosenwaks Z, Imperato-McGinley J

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In various tumor types, p53 mutations not only result in the loss of its tumor suppressor function but may also confer new oncogenic functions to the mutated p53, a phenomenon termed gain-of-function (GOF) ( The p53 protein plays a crucial role in cell cycle regulation and apoptosis