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Although the adapted program is the optimal solution under current conditions, if the intracellular stress signal persists and the ER function cannot return to normal, the apoptotic program might be initiated (291)

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In addition, Haller et al

Patients with AHR exhibit marked reductions in gut microbial diversity, particularly depletion of immunomodulatory taxa such as Bifidobacterium and Lactobacillus , which may compromise immune tolerance and exacerbate allergic sensitization ( Lactobacillus johnsonii supplementation reduces immune cell activation in lungs and Th2 cytokine expression (IL-4, IL-5, IL-13, IL-17), suggesting microbiota-targeted strategies for AHR modulation ( 6.2 Gut microbiota and airway remodeling Airway remodelingcharacterized by structural alterations like smooth muscle hypertrophy and subepithelial fibrosisis mechanistically influenced by gut microbiota via systemic inflammatory pathways